SkinCeuticals Phloretin CF Serum

Product Information

This broad-spectrum treatment provides advanced environmental protection to defend skin against the reactive molecules (including free radicals) that are known to cause cellular damage. In addition to its superior antioxidant capabilities, it has been proven to correct existing damage from the inside out. To study the anti-inflammatory effect of phloretin in vivo, Huang et al. [ 55] employed the LPS-induced lung injury model in mice where phloretin (20 mg/kg, intraperitoneal (i.p.)) was shown to suppress the upregulated neutrophil infiltration in lung tissue and reduce the levels of IL-6 and TNF-α in serum and bronchoalveolar lavage fluid. In the lung tissues, phloretin also suppressed the level of activity of MPO and superoxide dismutase (SOD) activity and decreased the gene expression levels of chemokines and proinflammatory cytokines (IL-1β, IL-6, TNF-α, MCP-1, and CCL5), intercellular adhesion molecule-1 (ICAM-1), iNOS, and COX-2 in inflamed lung tissues. The serum level of IL-6 and TNF-α were also suppressed in LPS-treated animals. As with the in vitro data, phloretin also reduced the phosphorylation of NF-κB and MAPK, while promoting the expression of haeme oxygenase (HO)-1 and nuclear factor erythroid 2-related factor 2 (Nrf2) [ 55]. In the lung model of inflammation induced by Mycobacteria tuberculosis, phloretin (2.5 or 5 mg/kg, i.p.) effectively suppressed the levels of TNF-α, IL-1β, and IL-6 in lung tissue [ 45]. The nonalcoholic fatty liver disease (NAFLD) experimental model is routinely used for the evaluation of therapeutic agents targeting the various components of metabolic dysfunction associated with lipids. By using Huh7 cells exposed to high doses of free fatty acids, Chhimwal et al. [ 68] have shown that phloretin encouraged autophagy-mediated hepatic lipid clearance and restored mitochondrial membrane potential and redox homeostasis. In the in vivo model of NAFLD using mice subjected to a western diet, a reduction in hepatic histological injury, hepatic lipogenesis, and enhanced fatty acid oxidation were observed in phloretin (50, 100, and 200 mg/kg, p.o.)-treated animals. While improving body weight, oral glucose tolerance, and antioxidant status in the liver (increased levels of SOD, CAT, and decreased lipid peroxidation products, malondialdehyde (MDA) status, a reduction in inflammation was evident as demonstrated by diminished levels of TNF-α and IL-6 in the liver. Beyond the anti-inflammatory effect, phloretin restored the AMPK activity (induction of phosphorylation of AMPK) in the liver of NAFLD and fatty acids-loaded hepatocyte cell lines. The activity of PPARα and its target genes carnitine palmitoyltransferase 1 (CPT1) and CPT2, as well as fatty acids metabolism in the liver, was also augmented by phloretin supplementation in the diet. Helps prevent free radical damage, diminishes the appearance of discolouration and improves skin tone and texture.

Phloretin CF works as a better choice for Normal, Oily and Combination skin types dealing with visible signs of ageing and discolouration. SkinCeuticals CE Ferulic is a better option for Normal, Dry and Sensitive skin types experiencing fine lines, wrinkles and loss of firmness, also working to brighten the skin. Once absorbed this antioxidant remains effective for a minimum of 72 hours, enhancing the benefits of your normal sunscreen.This antioxidant combination isn’t as well-researched as Vitamin C + Vitamin E + ferulic acid, so it may be less effective. Inhibits the proliferation of T lymphocytes; inhibits the expression of CD69 and CD25; induces cell cycle arrest at G0/G1 phase; reduces NO production of LPS-stimulated macrophages; reduces phagocytosis rate of macrophages. Phloretin CF provides powerful antioxidant protection, suitable for Normal, Oily and Combination skin types to improve discolouration, fine lines and wrinkles with its blend of phloretin, vitamin C and ferulic acid.

SkinCeuticals Phloretin CF is an advanced daytime antioxidant serum that provides superior environmental protection that is a pigment regulator helping to reduce dullness and discolouration of the skin, it retextures and evens skin tone for a brighter more radiant complexion. Suitable for normal, combination skin with ageing and hyperpigmentation. Decreases the mRNA level of IL-1β and TNF-α; inhibits the protein and mRNA upregulation of GLUT1 (but not GLUT3 and GLUT4) induced by LPS; inhibits glycolysis in LPS-treated macrophages in a GLUT1-dependent manner.Phloretin (at concentrations less than 100 µM) is known to inhibit adipogenesis and promote apoptosis in adipocytes in vitro [ 62, 63, 64]. In oleic acid-treated HepG2 cells, it also prevented excessive lipid accumulation and decreased the sterol regulatory element-binding protein 1c (SREBP-1c), inhibiting the expression of fatty acid synthase (FAS), while it increased the sirtuin 1 (SIRT1), and phosphorylation of AMPK to suppress acetyl-CoA carboxylase expression thereby suppressing the synthesis of fatty acids [ 65]. In high-fat-diet (HFD)-fed obese mice, phloretin reduced body weight and fat weight, liver weight and liver lipid accumulation, and improved hepatocyte steatosis. In liver tissue of obese mice, phloretin further suppressed transcription factors of lipogenesis and fatty acid synthase, and increased lipolysis and fatty acid β-oxidation. In addition, phloretin regulated serum leptin, adiponectin, triglyceride, low-density lipoprotein, and free fatty acid levels in obese mice [ 65]. The role of phloretin in lipid metabolism is, however, complex as it also promotes adipocyte differentiation in vitro and improves glucose homeostasis in vivo by increasing the expression of adipose-related genes or adipogenic markers (peroxisome proliferator-activated receptor-γ (PPARγ), CAAT enhancer binding protein-α (C/EBPα), fatty acid synthase, fatty acid-binding protein 4, and adiponectin such as fatty acids translocase and fatty acid synthase [ 64]. In this connection, phloretin is known to enhance adipocyte differentiation and adiponectin expression by mechanisms including PPARγ activation as well as modulation of gene expression with the implication of reducing insulin resistance [ 66]. When RAW 264.7 macrophages were co-cultured with 3T3-L1 cells during adipocytes differentiation, phloretin (and to a very less extent phlorizin) inhibited the adipogenesis-related transcription factors. The phosphorylation of AMPK and the activity of adipose triglyceride lipase and hormone-sensitive lipase were augmented. As an anti-inflammatory compound, phloretin also suppressed the NF-κB and MAPK pathways [ 67]. Its effects on obesity-associated inflammation are further scrutinised below. Do not store it in the fridge after it has been opened. Do not store in the sun as it will destabilise the ingredients. A mineral tinted fluid, this daily sunscreen is suitable for all skin types and instantly helps improve the appearance of uneven skin tone while protecting the skin from further discoloration and damage. Featuring micro-fine zinc oxide (Z-Cote®) and titanium dioxide to provide broad spectrum protection against UVA/UVB rays, this ultra-sheer, non-irritating formula is infused with artemia salina to enhance the skin’s natural defenses against UV- and heat-induced stress, plus translucent color spheres that help even out skin tone and boost skin’s radiance upon application. With a paraben- and fragrance-free, non-comedogenic formula that’s ideal for all skin types (including sensitive), this lightweight, water-resistant fluid provides a touch of coverage and leaves skin with a soft, radiant finish as well as no white cast. For evening use: Retinol 0.3, 0.5 or 1.0